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Activating Mutations in TOR Are in Similar Structures As Oncogenic Mutations in PI3KCα
[Image: see text] TOR (Target of Rapamycin) is a highly conserved Ser/Thr kinase and a central controller of cell growth. Using the crystal structure of the related lipid kinase PI3KCγ, we built a model of the catalytic region of TOR, from the FAT domain to near the end of the FATC domain. The model...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2009
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2796128/ https://www.ncbi.nlm.nih.gov/pubmed/19902965 http://dx.doi.org/10.1021/cb900193e |