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Trimethylamine N-oxide alleviates the severe aggregation and ER stress caused by G98R αA-crystallin

Purpose: Crystallins are major functional and structural proteins in mammalian lens. Their expression, distribution, and protein–protein interaction affect lens development and fiber cell differentiation. Mutated crystallins lead to structural and functional changes of lens structure and could lead...

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Detalles Bibliográficos
Autores principales: Gong, Bo, Zhang, Li-Yun, Pang, Chi-Pui, Lam, Dennis Shun-Chiu, Yam, Gary Hin-Fai
Formato: Texto
Lenguaje:English
Publicado: Molecular Vision 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2796635/
https://www.ncbi.nlm.nih.gov/pubmed/20029648