Ligand Depletion in vivo Modulates the Dynamic Range and Cooperativity of Signal Transduction

Biological signal transduction commonly involves cooperative interactions in the binding of ligands to their receptors. In many cases, ligand concentrations in vivo are close to the value of the dissociation constant of their receptors, resulting in the phenomenon of ligand depletion. Using examples...

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Detalles Bibliográficos
Autores principales: Edelstein, Stuart J., Stefan, Melanie I., Le Novère, Nicolas
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2797075/
https://www.ncbi.nlm.nih.gov/pubmed/20052284
http://dx.doi.org/10.1371/journal.pone.0008449

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2797075/
https://www.ncbi.nlm.nih.gov/pubmed/20052284
http://dx.doi.org/10.1371/journal.pone.0008449

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