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Ligand Depletion in vivo Modulates the Dynamic Range and Cooperativity of Signal Transduction
Biological signal transduction commonly involves cooperative interactions in the binding of ligands to their receptors. In many cases, ligand concentrations in vivo are close to the value of the dissociation constant of their receptors, resulting in the phenomenon of ligand depletion. Using examples...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2797075/ https://www.ncbi.nlm.nih.gov/pubmed/20052284 http://dx.doi.org/10.1371/journal.pone.0008449 |