Discovery of Novel Proteasome Inhibitors Using a High-Content Cell-Based Screening System

The regulated degradation of damaged or misfolded proteins, as well as down-regulation of key signaling proteins, within eukaryotic and bacterial cells is catalyzed primarily by large, ATP-dependent multimeric proteolytic complexes, termed proteasomes. Inhibition of proteasomal activity affects a wi...

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Detalles Bibliográficos
Autores principales: Lavelin, Irena, Beer, Avital, Kam, Zvi, Rotter, Varda, Oren, Moshe, Navon, Ami, Geiger, Benjamin
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2797363/
https://www.ncbi.nlm.nih.gov/pubmed/20041034
http://dx.doi.org/10.1371/journal.pone.0008503

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2797363/
https://www.ncbi.nlm.nih.gov/pubmed/20041034
http://dx.doi.org/10.1371/journal.pone.0008503

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