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Discovery of Novel Proteasome Inhibitors Using a High-Content Cell-Based Screening System
The regulated degradation of damaged or misfolded proteins, as well as down-regulation of key signaling proteins, within eukaryotic and bacterial cells is catalyzed primarily by large, ATP-dependent multimeric proteolytic complexes, termed proteasomes. Inhibition of proteasomal activity affects a wi...
| Autores principales: | , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2797363/ https://www.ncbi.nlm.nih.gov/pubmed/20041034 http://dx.doi.org/10.1371/journal.pone.0008503 |