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LDLR Expression and Localization Are Altered in Mouse and Human Cell Culture Models of Alzheimer's Disease

BACKGROUND: Alzheimer's disease (AD) is a chronic neurodegenerative disorder and the most common form of dementia. The major molecular risk factor for late-onset AD is expression of the ε-4 allele of apolipoprotein E (apoE), the major cholesterol transporter in the brain. The low-density lipopr...

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Detalles Bibliográficos
Autores principales:	Abisambra, Jose F., Fiorelli, Tina, Padmanabhan, Jaya, Neame, Peter, Wefes, Inge, Potter, Huntington
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2797391/ https://www.ncbi.nlm.nih.gov/pubmed/20049331 http://dx.doi.org/10.1371/journal.pone.0008556

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