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Co-Orientation of Replication and Transcription Preserves Genome Integrity

In many bacteria, there is a genome-wide bias towards co-orientation of replication and transcription, with essential and/or highly-expressed genes further enriched co-directionally. We previously found that reversing this bias in the bacterium Bacillus subtilis slows replication elongation, and we...

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Detalles Bibliográficos
Autores principales: Srivatsan, Anjana, Tehranchi, Ashley, MacAlpine, David M., Wang, Jue D.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2797598/
https://www.ncbi.nlm.nih.gov/pubmed/20090829
http://dx.doi.org/10.1371/journal.pgen.1000810