Co-Inhibition of BCL-W and BCL2 Restores Antiestrogen Sensitivity through BECN1 and Promotes an Autophagy-Associated Necrosis

BCL2 family members affect cell fate decisions in breast cancer but the role of BCL-W (BCL2L2) is unknown. We now show the integrated roles of the antiapoptotic BCL-W and BCL2 in affecting responsiveness to the antiestrogen ICI 182,780 (ICI; Fulvestrant Faslodex), using both molecular (siRNA; shRNA)...

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Detalles Bibliográficos
Autores principales: Crawford, Anatasha C., Riggins, Rebecca B., Shajahan, Ayesha N., Zwart, Alan, Clarke, Robert
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2797635/
https://www.ncbi.nlm.nih.gov/pubmed/20062536
http://dx.doi.org/10.1371/journal.pone.0008604

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2797635/
https://www.ncbi.nlm.nih.gov/pubmed/20062536
http://dx.doi.org/10.1371/journal.pone.0008604

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