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Co-Inhibition of BCL-W and BCL2 Restores Antiestrogen Sensitivity through BECN1 and Promotes an Autophagy-Associated Necrosis
BCL2 family members affect cell fate decisions in breast cancer but the role of BCL-W (BCL2L2) is unknown. We now show the integrated roles of the antiapoptotic BCL-W and BCL2 in affecting responsiveness to the antiestrogen ICI 182,780 (ICI; Fulvestrant Faslodex), using both molecular (siRNA; shRNA)...
Autores principales: | Crawford, Anatasha C., Riggins, Rebecca B., Shajahan, Ayesha N., Zwart, Alan, Clarke, Robert |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2797635/ https://www.ncbi.nlm.nih.gov/pubmed/20062536 http://dx.doi.org/10.1371/journal.pone.0008604 |
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