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Peripheral non-viral MIDGE vector-driven delivery of β-endorphin in inflammatory pain
BACKGROUND: Leukocytes infiltrating inflamed tissue produce and release opioid peptides such as β-endorphin, which activate opioid receptors on peripheral terminals of sensory nerves resulting in analgesia. Gene therapy is an attractive strategy to enhance continuous production of endogenous opioids...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2797781/ https://www.ncbi.nlm.nih.gov/pubmed/20003437 http://dx.doi.org/10.1186/1744-8069-5-72 |