Overexpression of Kinase-Negative Protein Kinase Cδ in Pancreatic β-Cells Protects Mice From Diet-Induced Glucose Intolerance and β-Cell Dysfunction

OBJECTIVE: In vitro models suggest that free fatty acid–induced apoptotic β-cell death is mediated through protein kinase C (PKC)δ. To examine the role of PKCδ signaling in vivo, transgenic mice overexpressing a kinase-negative PKCδ (PKCδKN) selectively in β-cells were generated and analyzed for glu...

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Detalles Bibliográficos
Autores principales: Hennige, Anita M., Ranta, Felicia, Heinzelmann, Isabel, Düfer, Martina, Michael, Diana, Braumüller, Heidi, Lutz, Stefan Z., Lammers, Reiner, Drews, Gisela, Bosch, Fatima, Häring, Hans-Ulrich, Ullrich, Susanne
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2010
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2797912/
https://www.ncbi.nlm.nih.gov/pubmed/19826167
http://dx.doi.org/10.2337/db09-0512

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2797912/
https://www.ncbi.nlm.nih.gov/pubmed/19826167
http://dx.doi.org/10.2337/db09-0512

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