Absence of p53-Dependent Apoptosis Combined With Nonhomologous End-Joining Deficiency Leads to a Severe Diabetic Phenotype in Mice

OBJECTIVE: Regulation of pancreatic β-cell mass is essential to preserve sufficient insulin levels for the maintenance of glucose homeostasis. Previously, we reported that DNA double-strand breaks (DSBs) resulting from nonhomologous end-joining (NHEJ) deficiency induce apoptosis and, when combined w...

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Detalles Bibliográficos
Autores principales: Tavana, Omid, Puebla-Osorio, Nahum, Sang, Mei, Zhu, Chengming
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2010
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2797914/
https://www.ncbi.nlm.nih.gov/pubmed/19833883
http://dx.doi.org/10.2337/db09-0792

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2797914/
https://www.ncbi.nlm.nih.gov/pubmed/19833883
http://dx.doi.org/10.2337/db09-0792

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