Hyperglycemia-Induced Reactive Oxygen Species Increase Expression of the Receptor for Advanced Glycation End Products (RAGE) and RAGE Ligands

OBJECTIVE: RAGE interacts with the endogenous ligands S100 calgranulins and high mobility group box 1 (HMGB1) to induce inflammation. Since hyperglycemia-induced reactive oxygen species (ROS) activate many pathways of diabetic tissue damage, the effect of these ROS on RAGE and RAGE ligand expression...

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Detalles Bibliográficos
Autores principales: Yao, Dachun, Brownlee, Michael
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2010
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2797929/
https://www.ncbi.nlm.nih.gov/pubmed/19833897
http://dx.doi.org/10.2337/db09-0801

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2797929/
https://www.ncbi.nlm.nih.gov/pubmed/19833897
http://dx.doi.org/10.2337/db09-0801

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