Polygenic Risk Variants for Type 2 Diabetes Susceptibility Modify Age at Diagnosis in Monogenic HNF1A Diabetes

OBJECTIVE: Mutations in the HNF1A gene are the most common cause of maturity-onset diabetes of the young (MODY). There is a substantial variation in the age at diabetes diagnosis, even within families where diabetes is caused by the same mutation. We investigated the hypothesis that common polygenic...

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Detalles Bibliográficos
Autores principales: Lango Allen, Hana, Johansson, Stefan, Ellard, Sian, Shields, Beverley, Hertel, Jens K., Ræder, Helge, Colclough, Kevin, Molven, Anders, Frayling, Timothy M., Njølstad, Pål R., Hattersley, Andrew T., Weedon, Michael N.
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2010
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2797932/
https://www.ncbi.nlm.nih.gov/pubmed/19794065
http://dx.doi.org/10.2337/db09-0555

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2797932/
https://www.ncbi.nlm.nih.gov/pubmed/19794065
http://dx.doi.org/10.2337/db09-0555

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