Cargando…

Quantitative Modeling of GRK-Mediated β2AR Regulation

We developed a unified model of the GRK-mediated β2 adrenergic receptor (β2AR) regulation that simultaneously accounts for six different biochemical measurements of the system obtained over a wide range of agonist concentrations. Using a single deterministic model we accounted for (1) GRK phosphoryl...

Descripción completa

Detalles Bibliográficos
Autores principales:	Vayttaden, Sharat J., Friedman, Jacqueline, Tran, Tuan M., Rich, Thomas C., Dessauer, Carmen W., Clark, Richard B.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2798957/ https://www.ncbi.nlm.nih.gov/pubmed/20098494 http://dx.doi.org/10.1371/journal.pcbi.1000647

Ejemplares similares

Roles of GRK and PDE4 Activities in the Regulation of β(2) Adrenergic Signaling
por: Xin, Wenkuan, et al.
Publicado: (2008)

Biased activation of β(2)-AR/Gi/GRK2 signal pathway attenuated β(1)-AR sustained activation induced by β(1)-adrenergic receptor autoantibody
por: Chen, Hao, et al.
Publicado: (2021)

Antagonistic Roles of GRK2 and GRK5 in Cardiac Aldosterone Signaling Reveal GRK5-Mediated Cardioprotection via Mineralocorticoid Receptor Inhibition
por: Maning, Jennifer, et al.
Publicado: (2020)

The β-blocker Nebivolol Is a GRK/β-arrestin Biased Agonist
por: Erickson, Catherine E., et al.
Publicado: (2013)

Fluvoxamine: A Review of Its Mechanism of Action and Its Role in COVID-19
por: Sukhatme, Vikas P., et al.
Publicado: (2021)

Trafficking GRK2: Cellular and Metabolic consequences of GRK2 subcellular localization.
por: Sorriento, Daniela, et al.
Publicado: (2014)

Suitability of GRK Antibodies for Individual Detection and Quantification of GRK Isoforms in Western Blots
por: Reichel, Mona, et al.
Publicado: (2022)

Differential Regulation of GPCRs—Are GRK Expression Levels the Key?
por: Matthees, Edda S. F., et al.
Publicado: (2021)

GRK Mediates μ-Opioid Receptor Plasma Membrane Reorganization
por: Gondin, Arisbel B., et al.
Publicado: (2019)

Myocardial GRK2 Reduces Fatty Acid Metabolism and β-Adrenergic Receptor-Mediated Mitochondrial Responses
por: Zhai, Ruxu, et al.
Publicado: (2022)

Multisite NHERF1 phosphorylation controls GRK6A regulation of hormone-sensitive phosphate transport
por: Vistrup-Parry, Maria, et al.
Publicado: (2021)

GRK2 regulates GLP-1R-mediated early phase insulin secretion in vivo
por: Arcones, Alba C., et al.
Publicado: (2021)

GRK5 Is Associated with the Regulation of Methadone Dosage in Heroin Dependence
por: Wang, Sheng-Chang, et al.
Publicado: (2018)

GRK5 is a regulator of fibroblast activation and cardiac fibrosis
por: Eguchi, Akito, et al.
Publicado: (2021)

Grk7 but not Grk1 undergoes cAMP-dependent phosphorylation in zebrafish cone photoreceptors and mediates cone photoresponse recovery to elevated cAMP
por: Chrispell, Jared D., et al.
Publicado: (2022)

Signal profiling of the β(1)AR reveals coupling to novel signalling pathways and distinct phenotypic responses mediated by β(1)AR and β(2)AR
por: Lukasheva, Viktoriya, et al.
Publicado: (2020)

Double life: How GRK2 and β-arrestin signaling participate in diseases
por: Zhai, Ruxu, et al.
Publicado: (2022)

Correction: Maning et al. Antagonistic Roles of GRK2 and GRK5 in Cardiac Aldosterone Signaling Reveal GRK5-Mediated Cardioprotection via Mineralocorticoid Receptor Inhibition. Int. J. Mol. Sci. 2020, 21, 2868
por: Maning, Jennifer, et al.
Publicado: (2021)

Grk1b and Grk7a Both Contribute to the Recovery of the Isolated Cone Photoresponse in Larval Zebrafish
por: Chrispell, Jared D., et al.
Publicado: (2018)

GRK2 differentially regulates FcεRI and MRGPRB2-mediated responses in mast cells
por: Thapaliya, Monica, et al.
Publicado: (2023)

Microtubule-Mediated Regulation of β(2)AR Translation and Function in Failing Hearts
por: Kwan, Zoe, et al.
Publicado: (2023)

Gαs is dispensable for β-arrestin coupling but dictates GRK selectivity and is predominant for gene expression regulation by β2-adrenergic receptor
por: Burghi, Valeria, et al.
Publicado: (2023)

Dissecting the roles of GRK2 and GRK3 in μ-opioid receptor internalization and β-arrestin2 recruitment using CRISPR/Cas9-edited HEK293 cells
por: Møller, Thor C., et al.
Publicado: (2020)

Effect of the 5-HT(4) receptor agonist tegaserod on the expression of GRK2 and GRK6 in the rat gastrointestinal tract
por: Nedi, Teshome, et al.
Publicado: (2018)

β2-Adrenoceptors and GRK2 as Potential Biomarkers in Patients With Chronic Pulmonary Regurgitation
por: Rodriguez-Serrano, María, et al.
Publicado: (2019)

GRK2-Mediated Crosstalk Between β-Adrenergic and Angiotensin II Receptors Enhances Adrenocortical Aldosterone Production In Vitro and In Vivo
por: Pollard, Celina M., et al.
Publicado: (2020)

GRK2 regulates group 2 innate lymphoid cell mobilization in sepsis
por: Lai, Dengming, et al.
Publicado: (2022)

ACKR4 Recruits GRK3 Prior to β-Arrestins but Can Scavenge Chemokines in the Absence of β-Arrestins
por: Matti, Christoph, et al.
Publicado: (2020)

Targeting cardiac β-adrenergic signaling via GRK2 inhibition for heart failure therapy
por: Cannavo, Alessandro, et al.
Publicado: (2013)

Modulation of CXCR4-Mediated Gi1 Activation by EGF Receptor and GRK2
por: Neves, Maria, et al.
Publicado: (2020)

Regulation of Constitutive GPR3 Signaling and Surface Localization by GRK2 and β-arrestin-2 Overexpression in HEK293 Cells
por: Lowther, Katie M., et al.
Publicado: (2013)

G Protein-Coupled Receptor Kinase 2 (GRK2) and 5 (GRK5) Exhibit Selective Phosphorylation of the Neurotensin Receptor in Vitro
por: Inagaki, Sayaka, et al.
Publicado: (2015)

Downregulation of GRK5 hampers the migration of breast cancer cells
por: Sommer, Ann-Katrin, et al.
Publicado: (2019)

GRK2 blockade with βARKct is essential for cardiac β(2)-adrenergic receptor signaling towards increased contractility
por: Salazar, Norma C, et al.
Publicado: (2013)

Dual role of GRK5 in cancer development and progression
por: Gambardella, J, et al.
Publicado: (2016)

Canonical and Non-Canonical Roles of GRK2 in Lymphocytes
por: Cheng, Jing, et al.
Publicado: (2021)

Targeting GRK5 for Treating Chronic Degenerative Diseases
por: Marzano, Federica, et al.
Publicado: (2021)

GRK3 as a Prognosis Biomarker in Gastric Cancer
por: Fang, Chia-Lang, et al.
Publicado: (2022)

Insights into cerebrovascular complications and Alzheimer disease through the selective loss of GRK2 regulation
por: Obrenovich, Mark E, et al.
Publicado: (2009)

GRK6 regulates ROS response and maintains hematopoietic stem cell self-renewal
por: Le, Qiumin, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_mfriqvli1s7l970rmjfeprd9k7