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A Novel Method to Adjust Efficacy Estimates for Uptake of Other Active Treatments in Long-Term Clinical Trials
BACKGROUND: When rates of uptake of other drugs differ between treatment arms in long-term trials, the true benefit or harm of the treatment may be underestimated. Methods to allow for such contamination have often been limited by failing to preserve the randomization comparisons. In the Fenofibrate...
Autores principales: | Simes, John, Voysey, Merryn, O'Connell, Rachel, Glasziou, Paul, Best, James D., Scott, Russell, Pardy, Christopher, Byth, Karen, Sullivan, David R., Ehnholm, Christian, Keech, Anthony |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2798963/ https://www.ncbi.nlm.nih.gov/pubmed/20072614 http://dx.doi.org/10.1371/journal.pone.0008580 |
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