Paradox of mistranslation of serine for alanine caused by AlaRS recognition dilemma

Mistranslation from confusion of serine for alanine by alanyl-tRNA synthetases (AlaRSs) has profound functional consequences1-3. Throughout evolution, two editing-checkpoints prevent disease-causing mistranslation from confusing glycine or serine for alanine at the active site of AlaRS. In both bact...

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Detalles Bibliográficos
Autores principales: Guo, Min, Chong, Yeeting E., Shapiro, Ryan, Beebe, Kirk, Yang, Xiang-Lei, Schimmel, Paul
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2799227/
https://www.ncbi.nlm.nih.gov/pubmed/20010690
http://dx.doi.org/10.1038/nature08612

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2799227/
https://www.ncbi.nlm.nih.gov/pubmed/20010690
http://dx.doi.org/10.1038/nature08612

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