Characterization of an engineered human purine nucleoside phosphorylase fused to an anti-her2/neu single chain Fv for use in ADEPT

BACKGROUND: Antibody Directed Enzyme Prodrug Therapy (ADEPT) can be used to generate cytotoxic agents at the tumor site. To date non-human enzymes have mainly been utilized in ADEPT. However, these non-human enzymes are immunogenic limiting the number of times that ADEPT can be administered. To over...

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Detalles Bibliográficos
Autores principales: Afshar, Sepideh, Olafsen, Tove, Wu, Anna M, Morrison, Sherie L
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2799393/
https://www.ncbi.nlm.nih.gov/pubmed/19958550
http://dx.doi.org/10.1186/1756-9966-28-147

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2799393/
https://www.ncbi.nlm.nih.gov/pubmed/19958550
http://dx.doi.org/10.1186/1756-9966-28-147

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