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Characterization of an engineered human purine nucleoside phosphorylase fused to an anti-her2/neu single chain Fv for use in ADEPT
BACKGROUND: Antibody Directed Enzyme Prodrug Therapy (ADEPT) can be used to generate cytotoxic agents at the tumor site. To date non-human enzymes have mainly been utilized in ADEPT. However, these non-human enzymes are immunogenic limiting the number of times that ADEPT can be administered. To over...
Autores principales: | Afshar, Sepideh, Olafsen, Tove, Wu, Anna M, Morrison, Sherie L |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2799393/ https://www.ncbi.nlm.nih.gov/pubmed/19958550 http://dx.doi.org/10.1186/1756-9966-28-147 |
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