PDGF-Rα gene expression predicts proliferation, but PDGF-A suppresses transdifferentiation of neonatal mouse lung myofibroblasts

BACKGROUND: Platelet-derived growth factor A (PDGF-A) signals solely through PDGF-Rα, and is required for fibroblast proliferation and transdifferentiation (fibroblast to myofibroblast conversion) during alveolar development, because pdgfa-null mice lack both myofibroblasts and alveoli. However, the...

Descripción completa

Detalles Bibliográficos
Autores principales: Kimani, Patricia W, Holmes, Amey J, Grossmann, Ruth E, McGowan, Stephen E
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2799395/
https://www.ncbi.nlm.nih.gov/pubmed/19939260
http://dx.doi.org/10.1186/1465-9921-10-119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2799395/
https://www.ncbi.nlm.nih.gov/pubmed/19939260
http://dx.doi.org/10.1186/1465-9921-10-119

Ejemplares similares