Structural and Mutational Analysis of Escherichia coli AlkB Provides Insight into Substrate Specificity and DNA Damage Searching

BACKGROUND: In Escherichia coli, cytotoxic DNA methyl lesions on the N1 position of purines and N3 position of pyrimidines are primarily repaired by the 2-oxoglutarate (2-OG) iron(II) dependent dioxygenase, AlkB. AlkB repairs 1-methyladenine (1-meA) and 3-methylcytosine (3-meC) lesions, but it also...

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Detalles Bibliográficos
Autores principales: Holland, Paul J., Hollis, Thomas
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2800194/
https://www.ncbi.nlm.nih.gov/pubmed/20084272
http://dx.doi.org/10.1371/journal.pone.0008680

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2800194/
https://www.ncbi.nlm.nih.gov/pubmed/20084272
http://dx.doi.org/10.1371/journal.pone.0008680

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