DNA topoisomerase I inhibition by camptothecin induces escape of RNA polymerase II from promoter-proximal pause site, antisense transcription and histone acetylation at the human HIF-1α gene locus

Top1 inhibition by camptothecin (CPT) perturbs RNA polymerase II (Pol II) density at promoters and along transcribed genes suggesting an involvement of Top1 in Pol II pausing. Here, we demonstrate that Top1 inhibition favors Pol II escape from a promoter-proximal pausing site of the human HIF-1α gen...

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Detalles Bibliográficos
Autores principales: Baranello, Laura, Bertozzi, Davide, Fogli, Maria Vittoria, Pommier, Yves, Capranico, Giovanni
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2010
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2800211/
https://www.ncbi.nlm.nih.gov/pubmed/19854946
http://dx.doi.org/10.1093/nar/gkp817

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2800211/
https://www.ncbi.nlm.nih.gov/pubmed/19854946
http://dx.doi.org/10.1093/nar/gkp817

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