Effect of NMSO3 treatment in a murine model of human metapneumovirus infection

BALB/c mice infected with human metapneumovirus (hMPV) were treated with the sulfated sialyl lipid NMSO3 (one dose of 50 mg kg(−1)) given at the time of infection. NMSO3 significantly reduced viral replication in the lungs, as well as hMPV-induced body weight loss, pulmonary inflammation and cytokin...

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Detalles Bibliográficos
Autores principales: Spetch, Leanne, Bowlin, Terry L., Casola, Antonella
Formato: Texto
Lenguaje:English
Publicado: Society for General Microbiology 2008
Materias:
Animal
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2800786/
https://www.ncbi.nlm.nih.gov/pubmed/18931066
http://dx.doi.org/10.1099/vir.0.2008/003301-0
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author Spetch, Leanne
Bowlin, Terry L.
Casola, Antonella
author_facet Spetch, Leanne
Bowlin, Terry L.
Casola, Antonella
author_sort Spetch, Leanne
collection PubMed
description BALB/c mice infected with human metapneumovirus (hMPV) were treated with the sulfated sialyl lipid NMSO3 (one dose of 50 mg kg(−1)) given at the time of infection. NMSO3 significantly reduced viral replication in the lungs, as well as hMPV-induced body weight loss, pulmonary inflammation and cytokine production, suggesting that antiviral treatment initiated at the beginning of viral infection can modify hMPV-induced disease.
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spelling pubmed-28007862009-12-31 Effect of NMSO3 treatment in a murine model of human metapneumovirus infection Spetch, Leanne Bowlin, Terry L. Casola, Antonella J Gen Virol Animal BALB/c mice infected with human metapneumovirus (hMPV) were treated with the sulfated sialyl lipid NMSO3 (one dose of 50 mg kg(−1)) given at the time of infection. NMSO3 significantly reduced viral replication in the lungs, as well as hMPV-induced body weight loss, pulmonary inflammation and cytokine production, suggesting that antiviral treatment initiated at the beginning of viral infection can modify hMPV-induced disease. Society for General Microbiology 2008-11 /pmc/articles/PMC2800786/ /pubmed/18931066 http://dx.doi.org/10.1099/vir.0.2008/003301-0 Text en Copyright © 2008, SGM http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Animal
Spetch, Leanne
Bowlin, Terry L.
Casola, Antonella
Effect of NMSO3 treatment in a murine model of human metapneumovirus infection
title Effect of NMSO3 treatment in a murine model of human metapneumovirus infection
title_full Effect of NMSO3 treatment in a murine model of human metapneumovirus infection
title_fullStr Effect of NMSO3 treatment in a murine model of human metapneumovirus infection
title_full_unstemmed Effect of NMSO3 treatment in a murine model of human metapneumovirus infection
title_short Effect of NMSO3 treatment in a murine model of human metapneumovirus infection
title_sort effect of nmso3 treatment in a murine model of human metapneumovirus infection
topic Animal
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2800786/
https://www.ncbi.nlm.nih.gov/pubmed/18931066
http://dx.doi.org/10.1099/vir.0.2008/003301-0
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AT casolaantonella effectofnmso3treatmentinamurinemodelofhumanmetapneumovirusinfection

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