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Switch Region for Pathogenic Structural Change in Conformational Disease and Its Prediction
Many diseases are believed to be related to abnormal protein folding. In the first step of such pathogenic structural changes, misfolding occurs in regions important for the stability of the native structure. This destabilizes the normal protein conformation, while exposing the previously hidden agg...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2010
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2801591/ https://www.ncbi.nlm.nih.gov/pubmed/20111584 http://dx.doi.org/10.1371/journal.pone.0008441 |