Binding of Natural and Synthetic Polyphenols to Human Dihydrofolate Reductase

Dihydrofolate reductase (DHFR) is the subject of intensive investigation since it appears to be the primary target enzyme for antifolate drugs. Fluorescence quenching experiments show that the ester bond-containing tea polyphenols (-)-epigallocatechin gallate (EGCG) and (-)-epicatechin gallate (ECG)...

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Detalles Bibliográficos
Autores principales: Sánchez-del-Campo, Luís, Sáez-Ayala, Magalí, Chazarra, Soledad, Cabezas-Herrera, Juan, Rodríguez-López, José Neptuno
Formato: Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2802001/
https://www.ncbi.nlm.nih.gov/pubmed/20054477
http://dx.doi.org/10.3390/ijms10125398

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2802001/
https://www.ncbi.nlm.nih.gov/pubmed/20054477
http://dx.doi.org/10.3390/ijms10125398

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