Development of Improved Models for Phosphodiesterase-4 Inhibitors with a Multi-Conformational Structure-Based QSAR Method

Phosphodiesterase-4 (PDE-4) is an important drug target for several diseases, including COPD (chronic obstructive pulmonary disorder) and neurodegenerative diseases. In this paper, we describe the development of improved QSAR (quantitative structure-activity relationship) models using a novel multi-...

Descripción completa

Detalles Bibliográficos
Autores principales: Adekoya, Adetokunbo, Dong, Xialan, Ebalunode, Jerry, Zheng, Weifan
Formato: Texto
Lenguaje:English
Publicado: Bentham Open 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2802764/
https://www.ncbi.nlm.nih.gov/pubmed/20161837
http://dx.doi.org/10.2174/1875397300903010054

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2802764/
https://www.ncbi.nlm.nih.gov/pubmed/20161837
http://dx.doi.org/10.2174/1875397300903010054

Ejemplares similares