Cargando…

Development of Improved Models for Phosphodiesterase-4 Inhibitors with a Multi-Conformational Structure-Based QSAR Method

Phosphodiesterase-4 (PDE-4) is an important drug target for several diseases, including COPD (chronic obstructive pulmonary disorder) and neurodegenerative diseases. In this paper, we describe the development of improved QSAR (quantitative structure-activity relationship) models using a novel multi-...

Descripción completa

Detalles Bibliográficos
Autores principales:	Adekoya, Adetokunbo, Dong, Xialan, Ebalunode, Jerry, Zheng, Weifan
Formato:	Texto
Lenguaje:	English
Publicado:	Bentham Open 2009
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2802764/ https://www.ncbi.nlm.nih.gov/pubmed/20161837 http://dx.doi.org/10.2174/1875397300903010054

Ejemplares similares

A New Structure-Based QSAR Method Affords both Descriptive and Predictive Models for Phosphodiesterase-4 Inhibitors
por: Dong, Xialan, et al.
Publicado: (2008)

Cheminformatics Modeling of Gene Silencing for Both Natural and Chemically Modified siRNAs
por: Dong, Xialan, et al.
Publicado: (2022)

3D-QSAR Study of Potent Inhibitors of Phosphodiesterase-4 Using a CoMFA Approach
por: Yang, Zhaoqi, et al.
Publicado: (2007)

Recent Advances in Fragment-Based QSAR and Multi-Dimensional QSAR Methods
por: Myint, Kyaw Zeyar, et al.
Publicado: (2010)

Coupling of conformational dynamics and inhibitor binding in the phosphodiesterase‐5 family
por: Tripathi, Shubhandra, et al.
Publicado: (2023)

Large scale comparison of QSAR and conformal prediction methods and their applications in drug discovery
por: Bosc, Nicolas, et al.
Publicado: (2019)

2D-QSAR and 3D-QSAR Analyses for EGFR Inhibitors
por: Zhao, Manman, et al.
Publicado: (2017)

Literature-Wide Association Studies (LWAS) for a Rare Disease: Drug Repurposing for Inflammatory Breast Cancer
por: Ji, Xiaojia, et al.
Publicado: (2020)

Oncogenic Role of Tumor Necrosis Factor α-Induced Protein 8 (TNFAIP8)
por: Niture, Suryakant, et al.
Publicado: (2018)

Missed opportunities in large scale comparison of QSAR and conformal prediction methods and their applications in drug discovery
por: Krstajic, Damjan
Publicado: (2019)

Reply to “Missed opportunities in large scale comparison of QSAR and conformal prediction methods and their applications in drug discovery”
por: Bosc, Nicolas, et al.
Publicado: (2019)

Is conformation a fundamental descriptor in QSAR? A case for halogenated anesthetics
por: Guimarães, Maria C, et al.
Publicado: (2016)

TNFAIP8 regulates autophagy, cell steatosis, and promotes hepatocellular carcinoma cell proliferation
por: Niture, Suryakant, et al.
Publicado: (2020)

Evolution of Phosphodiesterase-5 Inhibitors
por: Moon, Du Geon
Publicado: (2015)

Effect of phosphodiesterase inhibitors in the bladder
por: Chughtai, Bilal, et al.
Publicado: (2015)

Improvement of quantitative structure–activity relationship (QSAR) tools for predicting Ames mutagenicity: outcomes of the Ames/QSAR International Challenge Project
por: Honma, Masamitsu, et al.
Publicado: (2019)

Phosphodiesterase Inhibitor Improves Renal Tubulointerstitial Hypoxia of the Diabetic Rat Kidney
por: Sun, Hui-Kyoung, et al.
Publicado: (2012)

Phosphodiesterase 4 inhibitor apremilast improves insulin resistance in psoriasis patients
por: Ikumi, Kyoko, et al.
Publicado: (2021)

QSAR analysis on tacrine-related acetylcholinesterase inhibitors
por: Wong, Kai Y, et al.
Publicado: (2014)

Convergent QSAR Models for the Prediction of Cruzain Inhibitors
por: Gonçalves, Rafael Bello, et al.
Publicado: (2023)

Effect of Phosphodiesterase Inhibitor on Diabetic Nephropathy
por: Kang, Shin-Wook
Publicado: (2012)

Repurposing phosphodiesterase-5 inhibitors as chemoadjuvants
por: Tiwari, Amit K., et al.
Publicado: (2013)

Phosphodiesterase inhibitors as adjunctive therapies for tuberculosis
por: Ahidjo, Bintou Ahmadou, et al.
Publicado: (2016)

New Avenues for Phosphodiesterase Inhibitors in Asthma
por: Matera, Maria Gabriella, et al.
Publicado: (2021)

Multi-target QSAR modelling in the analysis and design of HIV-HCV co-inhibitors: an in-silico study
por: Liu, Qi, et al.
Publicado: (2011)

Structure Modeling of Human Tyrosyl-DNA Phosphodiesterase 1 and Screening for Its Inhibitors
por: Gushchina, I.V., et al.
Publicado: (2017)

QSAR Modeling for Multi-Target Drug Discovery: Designing Simultaneous Inhibitors of Proteins in Diverse Pathogenic Parasites
por: Kleandrova, Valeria V., et al.
Publicado: (2021)

QSAR Studies on Andrographolide Derivatives as α-Glucosidase Inhibitors
por: Xu, Jun, et al.
Publicado: (2010)

QSAR Accelerated Discovery of Potent Ice Recrystallization Inhibitors
por: Briard, Jennie G., et al.
Publicado: (2016)

QSAR Study of N-Myristoyltransferase Inhibitors of Antimalarial Agents
por: Santos-Garcia, Letícia, et al.
Publicado: (2018)

Azole Compounds as Inhibitors of Candida albicans: QSAR Modelling
por: Gheidari, Davood, et al.
Publicado: (2021)

Selective Phosphodiesterase Inhibitors for Psoriasis: Focus on Apremilast
por: Gooderham, Melinda, et al.
Publicado: (2015)

Chemotherapeutic Efficacy of Phosphodiesterase Inhibitors in Chagasic Cardiomyopathy
por: Wen, Jian-jun, et al.
Publicado: (2016)

Phosphodiesterase-4 Inhibitors for the Treatment of Inflammatory Diseases
por: Li, Heng, et al.
Publicado: (2018)

Phosphodiesterase-5 inhibitors for colon cancer chemoprevention
por: Islam, Bianca N., et al.
Publicado: (2018)

Phosphodiesterase-5 inhibitors and the heart: compound cardioprotection?
por: Hutchings, David Charles, et al.
Publicado: (2018)

Phosphodiesterase-5 inhibitors: Emerging nephroprotective drugs
por: Abassi, Zaid, et al.
Publicado: (2015)

Methylxanthines and Phosphodiesterase Inhibitors in the Treatment of Airways Disease
por: Semple, S J G
Publicado: (1995)

Phosphodiesterase 4 Inhibitors in Allergic Rhinitis/Rhinosinusitis
por: Janosova, Viera, et al.
Publicado: (2020)

Effect and Mechanism of Phosphodiesterase Inhibitors on Trabecular Outflow
por: Kim, Jae Woo, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_ofiivm93v0eu0n9bffmgmo9uqv