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A High Throughput Serum Paraoxonase Assay for Discovery of Small Molecule Modulators of PON1 Activity
PON1 has been demonstrated to be the serum enzyme responsible for detoxifying organophosphate chemical weapons and plays a protective role against atherosclerosis. In order to identify small molecules that modulate PON1 activity in serum, we developed a high throughput kinetic absorbance assay using...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Bentham Open
2008
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2803440/ https://www.ncbi.nlm.nih.gov/pubmed/20161844 http://dx.doi.org/10.2174/1875397300802010051 |