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A High Throughput Serum Paraoxonase Assay for Discovery of Small Molecule Modulators of PON1 Activity

PON1 has been demonstrated to be the serum enzyme responsible for detoxifying organophosphate chemical weapons and plays a protective role against atherosclerosis. In order to identify small molecules that modulate PON1 activity in serum, we developed a high throughput kinetic absorbance assay using...

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Detalles Bibliográficos
Autores principales:	Graves, Tiffany L, Scott, John E
Formato:	Texto
Lenguaje:	English
Publicado:	Bentham Open 2008
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2803440/ https://www.ncbi.nlm.nih.gov/pubmed/20161844 http://dx.doi.org/10.2174/1875397300802010051

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