Activation of PKA, p38 MAPK and ERK1/2 by gonadotropins in cumulus cells is critical for induction of EGF-like factor and TACE/ADAM17 gene expression during in vitro maturation of porcine COCs

OBJECTIVES: During ovulation, it has been shown that LH stimulus induces the expression of numerous genes via PKA, p38 MAPK, PI3K and ERK1/2 in cumulus cells and granulosa cells. Our recent study showed that EGF-like factor and its protease (TACE/ADAM17) are required for the activation of EGF recept...

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Detalles Bibliográficos
Autores principales: Yamashita, Yasuhisa, Hishinuma, Mitsugu, Shimada, Masayuki
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2803446/
https://www.ncbi.nlm.nih.gov/pubmed/20034375
http://dx.doi.org/10.1186/1757-2215-2-20

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2803446/
https://www.ncbi.nlm.nih.gov/pubmed/20034375
http://dx.doi.org/10.1186/1757-2215-2-20

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