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MTHFR polymorphisms in gastric cancer and in first-degree relatives of patients with gastric cancer
Two common mutations, 677 C→T and a1298 A→C, in the methylenetetrahydrofolate reductase gene (MTHFR) reduce the activity of MTHFR and folate metabolism. Familial aggregation in a variable but significant proportion of gastric cancer (GC) cases suggests the importance of genetic predisposition in det...
Autores principales: | De Re, Valli, Cannizzaro, R., Canzonieri, V., Cecchin, E., Caggiari, L., De Mattia, E., Pratesi, C., De Paoli, P., Toffoli, G. |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Springer Netherlands
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2803747/ https://www.ncbi.nlm.nih.gov/pubmed/20237899 http://dx.doi.org/10.1007/s13277-009-0004-1 |
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