Keratin 18 attenuates estrogen receptor α-mediated signaling by sequestering LRP16 in cytoplasm

BACKGROUND: Oncogenesis in breast cancer is often associated with excess estrogen receptor α(ERα) activation and overexpression of its coactivators. LRP16 is both an ERα target gene and an ERα coactivator, and plays a crucial role in ERα activation and proliferation of MCF-7 breast cancer cells. How...

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Detalles Bibliográficos
Autores principales: Meng, Yuanguang, Wu, Zhiqiang, Yin, Xiaoyun, Zhao, Yali, Chen, Meixia, Si, Yiling, Yang, Jie, Fu, Xiaobing, Han, Weidong
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2804594/
https://www.ncbi.nlm.nih.gov/pubmed/20035625
http://dx.doi.org/10.1186/1471-2121-10-96

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2804594/
https://www.ncbi.nlm.nih.gov/pubmed/20035625
http://dx.doi.org/10.1186/1471-2121-10-96

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