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Keratin 18 attenuates estrogen receptor α-mediated signaling by sequestering LRP16 in cytoplasm
BACKGROUND: Oncogenesis in breast cancer is often associated with excess estrogen receptor α(ERα) activation and overexpression of its coactivators. LRP16 is both an ERα target gene and an ERα coactivator, and plays a crucial role in ERα activation and proliferation of MCF-7 breast cancer cells. How...
| Autores principales: | , , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2804594/ https://www.ncbi.nlm.nih.gov/pubmed/20035625 http://dx.doi.org/10.1186/1471-2121-10-96 |