Recombinant protein expression by targeting pre-selected chromosomal loci

BACKGROUND: Recombinant protein expression in mammalian cells is mostly achieved by stable integration of transgenes into the chromosomal DNA of established cell lines. The chromosomal surroundings have strong influences on the expression of transgenes. The exploitation of defined loci by targeting...

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Detalles Bibliográficos
Autores principales: Nehlsen, Kristina, Schucht, Roland, da Gama-Norton, Leonor, Krömer, Wolfgang, Baer, Alexandra, Cayli, Aziz, Hauser, Hansjörg, Wirth, Dagmar
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2804664/
https://www.ncbi.nlm.nih.gov/pubmed/20003421
http://dx.doi.org/10.1186/1472-6750-9-100

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2804664/
https://www.ncbi.nlm.nih.gov/pubmed/20003421
http://dx.doi.org/10.1186/1472-6750-9-100

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