Cargando…

Presynaptic CaV2 calcium channel traffic requires CALF-1 and the alpha2-delta subunit UNC-36

Presynaptic voltage-gated calcium channels provide calcium for synaptic vesicle exocytosis. We show here that a GFP-tagged alpha1 subunit of the C. elegans CaV2 channel, UNC-2, is localized to presynaptic active zones of sensory and motor neurons. Synaptic localization of CaV2 requires the alpha2-de...

Descripción completa

Detalles Bibliográficos
Autores principales:	Saheki, Yasunori, Bargmann, Cornelia I.
Formato:	Texto
Lenguaje:	English
Publicado:	2009
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2805665/ https://www.ncbi.nlm.nih.gov/pubmed/19718034 http://dx.doi.org/10.1038/nn.2383

Ejemplares similares

Gain-of-function mutations in the UNC-2/CaV2α channel lead to excitation-dominant synaptic transmission in Caenorhabditis elegans
por: Huang, Yung-Chi, et al.
Publicado: (2019)

The Caenorhabditis elegans voltage-gated calcium channel subunits UNC-2 and UNC-36 and the calcium-dependent kinase UNC-43/CaMKII regulate neuromuscular junction morphology
por: Caylor, Raymond C, et al.
Publicado: (2013)

Presynaptic BK channel localization is dependent on the hierarchical organization of alpha-catulin and dystrobrevin and fine-tuned by CaV2 calcium channels
por: Oh, Kelly H, et al.
Publicado: (2015)

Ethanol Regulates Presynaptic Activity and Sedation through Presynaptic Unc13 Proteins in Drosophila
por: Xu, Shiyu, et al.
Publicado: (2018)

Inter-channel scaffolding of presynaptic CaV2.2 via the C terminal PDZ ligand domain
por: Gardezi, Sabiha R., et al.
Publicado: (2013)

alpha2delta expression sets presynaptic calcium channel abundance and release probability
por: Hoppa, Michael B., et al.
Publicado: (2012)

Ontogenic Changes and Differential Localization of T-type Ca(2+) Channel Subunits Cav3.1 and Cav3.2 in Mouse Hippocampus and Cerebellum
por: Aguado, Carolina, et al.
Publicado: (2016)

Molecular Characterization of an SV Capture Site in the Mid-Region of the Presynaptic CaV2.1 Calcium Channel C-Terminal
por: Snidal, Christine A., et al.
Publicado: (2018)

Presynaptic α(2)δ subunits are key organizers of glutamatergic synapses
por: Schöpf, Clemens L., et al.
Publicado: (2021)

The short coiled-coil domain-containing protein UNC-69 cooperates with UNC-76 to regulate axonal outgrowth and normal presynaptic organization in Caenorhabditis elegans
por: Su, Cheng-Wen, et al.
Publicado: (2006)

Analgesia by intrathecal delta-9-tetrahydrocannabinol is dependent on Cav3.2 calcium channels
por: Gadotti, Vinicius de Maria, et al.
Publicado: (2023)

CaV1 and CaV2 calcium channels mediate the release of distinct pools of synaptic vesicles
por: Mueller, Brian D, et al.
Publicado: (2023)

Endogenous tagging of Unc-13 reveals nanoscale reorganization at active zones during presynaptic homeostatic potentiation
por: Dannhäuser, Sven, et al.
Publicado: (2022)

New Insights in CaVβ Subunits: Role in the Regulation of Gene Expression and Cellular Homeostasis
por: Vergnol, Amélie, et al.
Publicado: (2022)

Comparison of quinazoline and benzoylpyrazoline chemotypes targeting the CaVα-β interaction as antagonists of the N-type CaV2.2 channel
por: Ran, Dongzhi, et al.
Publicado: (2021)

unc-33/CRMP and ankyrin organize microtubules and localize kinesin to polarize axon-dendrite sorting
por: Maniar, Tapan A., et al.
Publicado: (2011)

Synaptic vesicle capture by CaV2.2 calcium channels
por: Wong, Fiona K., et al.
Publicado: (2013)

UNC79 and UNC80, Putative Auxiliary Subunits of the NARROW ABDOMEN Ion Channel, Are Indispensable for Robust Circadian Locomotor Rhythms in Drosophila
por: Lear, Bridget C., et al.
Publicado: (2013)

A Comprehensive Eco-Driving Strategy for CAVs with Microscopic Traffic Simulation Testing Evaluation
por: Kavas-Torris, Ozgenur, et al.
Publicado: (2023)

β2-subunit alternative splicing stabilizes Cav2.3 Ca(2+) channel activity during continuous midbrain dopamine neuron-like activity
por: Siller, Anita, et al.
Publicado: (2022)

Synaptic vesicle tethering and the CaV2.2 distal C-terminal
por: Wong, Fiona K., et al.
Publicado: (2014)

Restraint of presynaptic protein levels by Wnd/DLK signaling mediates synaptic defects associated with the kinesin-3 motor Unc-104
por: Li, Jiaxing, et al.
Publicado: (2017)

Prognostic Value of CAV1 and CAV2 in Head and Neck Squamous Cell Carcinoma
por: He, Jingyu, et al.
Publicado: (2023)

Ca(2+)/Calmodulin and Presynaptic Short-Term Plasticity
por: Mochida, Sumiko
Publicado: (2011)

Bipolar‐associated miR‐499‐5p controls neuroplasticity by downregulating the Cav1.2 subunit CACNB2
por: Martins, Helena C, et al.
Publicado: (2022)

Ethnic specific association of the CAV1/CAV2 locus with primary open-angle glaucoma
por: Rong, Shi Song, et al.
Publicado: (2016)

Opposing functions for retromer and Rab11 in extracellular vesicle traffic at presynaptic terminals
por: Walsh, Rylie B., et al.
Publicado: (2021)

C. elegans Clarinet/CLA-1 recruits RIMB-1/RIM-binding protein and UNC-13 to orchestrate presynaptic neurotransmitter release
por: Krout, Mia, et al.
Publicado: (2023)

Redetermination of metarossite, CaV(5+) (2)O(6)·2H(2)O
por: Kobsch, Anaïs, et al.
Publicado: (2016)

The UNC-6/Netrin receptors UNC-40/DCC and UNC-5 inhibit growth cone filopodial protrusion via UNC-73/Trio, Rac-like GTPases and UNC-33/CRMP
por: Norris, Adam D., et al.
Publicado: (2014)

UNC-129 regulates the balance between UNC-40 dependent and independent UNC-5 signaling pathways
por: MacNeil, Lesley T., et al.
Publicado: (2009)

GABA(B) receptor auxiliary subunits modulate Cav2.3-mediated release from medial habenula terminals
por: Bhandari, Pradeep, et al.
Publicado: (2021)

Functional Exploration Of T-Type Calcium Channels (Cav3.2 And Cav3.3) And Their Sensitivity To Zinc
por: Hazzaz Abouamal, Tahar, et al.
Publicado: (2018)

Post-mortem gene expression of calcium channels Cav1.2 and Cav1.3 in schizophrenia
por: Schmitt, Andrea, et al.
Publicado: (2022)

The Core Complex of the Ca(2+)-Triggered Presynaptic Fusion Machinery
por: Brunger, Axel T., et al.
Publicado: (2023)

Capsaicin-Induced Endocytosis of Endogenous Presynaptic Ca(V)2.2 in DRG-Spinal Cord Co-Cultures Inhibits Presynaptic Function
por: Ramgoolam, Krishma H, et al.
Publicado: (2022)

Lack of association of SNP rs4236601 near CAV1 and CAV2 with POAG in a Saudi cohort
por: Abu-Amero, Khaled K., et al.
Publicado: (2012)

Expression-associated polymorphisms of CAV1-CAV2 affect intraocular pressure and high-tension glaucoma risk
por: Kim, Sewon, et al.
Publicado: (2015)

Sensory Transduction Channel Subunits, tax-4 and tax-2, Modify Presynaptic Molecular Architecture in C. elegans
por: Hellman, Andrew B., et al.
Publicado: (2011)

Left-right olfactory asymmetry results from antagonistic functions of voltage-activated calcium channels and the Raw repeat protein OLRN-1 in C. elegans
por: Bauer Huang, Sarah L, et al.
Publicado: (2007)

Cannot write session to /tmp/vufind_sessions/sess_5qagk6u9p83i1fqe6q4g0bsem5