Chloroquine reduces arylsulphatase B activity and increases chondroitin-4-sulphate: implications for mechanisms of action and resistance

BACKGROUND: The receptors for adhesion of Plasmodium falciparum-infected red blood cells (RBC) in the placenta have been identified as chondroitin-4-sulphate (C4S) proteoglycans, and the more sulphate-rich chondroitin oligosaccharides have been reported to inhibit adhesion. Since the anti-malarial d...

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Detalles Bibliográficos
Autores principales: Bhattacharyya, Sumit, Solakyildirim, Kemal, Zhang, Zhenqing, Linhardt, Robert J, Tobacman, Joanne K
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2805689/
https://www.ncbi.nlm.nih.gov/pubmed/20017940
http://dx.doi.org/10.1186/1475-2875-8-303

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2805689/
https://www.ncbi.nlm.nih.gov/pubmed/20017940
http://dx.doi.org/10.1186/1475-2875-8-303

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