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Chloroquine reduces arylsulphatase B activity and increases chondroitin-4-sulphate: implications for mechanisms of action and resistance
BACKGROUND: The receptors for adhesion of Plasmodium falciparum-infected red blood cells (RBC) in the placenta have been identified as chondroitin-4-sulphate (C4S) proteoglycans, and the more sulphate-rich chondroitin oligosaccharides have been reported to inhibit adhesion. Since the anti-malarial d...
Autores principales: | Bhattacharyya, Sumit, Solakyildirim, Kemal, Zhang, Zhenqing, Linhardt, Robert J, Tobacman, Joanne K |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2805689/ https://www.ncbi.nlm.nih.gov/pubmed/20017940 http://dx.doi.org/10.1186/1475-2875-8-303 |
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