Hidden alternate structures of proline isomerase essential for catalysis

A longstanding challenge is to understand at the atomic level how protein dynamics contribute to enzyme catalysis. X-ray crystallography can provide snapshots of conformational substates sampled during enzymatic reactions1, while NMR relaxation methods reveal the rates of interconversion between sub...

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Detalles Bibliográficos
Autores principales: Fraser, James S., Clarkson, Michael W., Degnan, Sheena C., Erion, Renske, Kern, Dorothee, Alber, Tom
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2805857/
https://www.ncbi.nlm.nih.gov/pubmed/19956261
http://dx.doi.org/10.1038/nature08615

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2805857/
https://www.ncbi.nlm.nih.gov/pubmed/19956261
http://dx.doi.org/10.1038/nature08615

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