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Hidden alternate structures of proline isomerase essential for catalysis

A longstanding challenge is to understand at the atomic level how protein dynamics contribute to enzyme catalysis. X-ray crystallography can provide snapshots of conformational substates sampled during enzymatic reactions1, while NMR relaxation methods reveal the rates of interconversion between sub...

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Detalles Bibliográficos
Autores principales:	Fraser, James S., Clarkson, Michael W., Degnan, Sheena C., Erion, Renske, Kern, Dorothee, Alber, Tom
Formato:	Texto
Lenguaje:	English
Publicado:	2009
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2805857/ https://www.ncbi.nlm.nih.gov/pubmed/19956261 http://dx.doi.org/10.1038/nature08615

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