Calorie restriction reduces rDNA recombination independently of rDNA silencing

Calorie restriction (CR) extends lifespan in yeast, worms, flies and mammals, suggesting that it acts via a conserved mechanism. In yeast, activation of the NAD-dependent histone deacetylase, Sir2, by CR is thought to increase silencing at the ribosomal DNA, thereby reducing the recombination-induce...

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Detalles Bibliográficos
Autores principales: Riesen, Michèle, Morgan, Alan
Formato: Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2009
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2805862/
https://www.ncbi.nlm.nih.gov/pubmed/19732046
http://dx.doi.org/10.1111/j.1474-9726.2009.00514.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2805862/
https://www.ncbi.nlm.nih.gov/pubmed/19732046
http://dx.doi.org/10.1111/j.1474-9726.2009.00514.x

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