WRN helicase defective in the premature aging disorder Werner syndrome genetically interacts with topoisomerase 3 and restores the top3 slow growth phenotype of sgs1 top3

Werner syndrome (WS) is a premature aging disorder characterized by genomic instability. The WRN gene defective in WS encodes a protein with both helicase and exonuclease activities that interacts with proteins implicated in DNA metabolism. To understand its genetic functions, we examined the abilit...

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Detalles Bibliográficos
Autores principales: Aggarwal, Monika, Brosh, Robert M.
Formato: Texto
Lenguaje:English
Publicado: Impact Journals LLC 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806000/
https://www.ncbi.nlm.nih.gov/pubmed/20157511

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806000/
https://www.ncbi.nlm.nih.gov/pubmed/20157511

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