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Divergence of allosteric effects of rapacuronium on binding and function of muscarinic receptors

BACKGROUND: Many neuromuscular blockers act as negative allosteric modulators of muscarinic acetylcholine receptors by decreasing affinity and potency of acetylcholine. The neuromuscular blocker rapacuronium has been shown to have facilitatory effects at muscarinic receptors leading to bronchospasm....

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Detalles Bibliográficos
Autores principales: Jakubík, Jan, Randáková, Alena, El-Fakahany, Esam E, Doležal, Vladimír
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806265/
https://www.ncbi.nlm.nih.gov/pubmed/20038295
http://dx.doi.org/10.1186/1471-2210-9-15