Inducible proteolytic inactivation of OPA1 mediated by the OMA1 protease in mammalian cells

The mammalian mitochondrial inner membrane fusion protein OPA1 is controlled by complex patterns of alternative splicing and proteolysis. A subset of OPA1 isoforms is constitutively cleaved by YME1L. Other isoforms are not cleaved by YME1L, but they are cleaved when mitochondria lose membrane potent...

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Detalles Bibliográficos
Autores principales: Head, Brian, Griparic, Lorena, Amiri, Mandana, Gandre-Babbe, Shilpa, van der Bliek, Alexander M.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2009
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806274/
https://www.ncbi.nlm.nih.gov/pubmed/20038677
http://dx.doi.org/10.1083/jcb.200906083

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806274/
https://www.ncbi.nlm.nih.gov/pubmed/20038677
http://dx.doi.org/10.1083/jcb.200906083

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