Cellular IAPs inhibit a cryptic CD95-induced cell death by limiting RIP1 kinase recruitment

A role for cellular inhibitors of apoptosis (IAPs [cIAPs]) in preventing CD95 death has been suspected but not previously explained mechanistically. In this study, we find that the loss of cIAPs leads to a dramatic sensitization to CD95 ligand (CD95L) killing. Surprisingly, this form of cell death c...

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Detalles Bibliográficos
Autores principales: Geserick, Peter, Hupe, Mike, Moulin, Maryline, Wong, W. Wei-Lynn, Feoktistova, Maria, Kellert, Beate, Gollnick, Harald, Silke, John, Leverkus, Martin
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2009
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806279/
https://www.ncbi.nlm.nih.gov/pubmed/20038679
http://dx.doi.org/10.1083/jcb.200904158

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806279/
https://www.ncbi.nlm.nih.gov/pubmed/20038679
http://dx.doi.org/10.1083/jcb.200904158

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