Overall Cdk activity modulates the DNA damage response in mammalian cells

In response to DNA damage, cells activate a phosphorylation-based signaling cascade known as the DNA damage response (DDR). One of the main outcomes of DDR activation is inhibition of cyclin-dependent kinase (Cdk) activity to restrain cell cycle progression until lesions are healed. Recent studies h...

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Detalles Bibliográficos
Autores principales: Cerqueira, Antonio, Santamaría, David, Martínez-Pastor, Bárbara, Cuadrado, Miriam, Fernández-Capetillo, Oscar, Barbacid, Mariano
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2009
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806328/
https://www.ncbi.nlm.nih.gov/pubmed/19995934
http://dx.doi.org/10.1083/jcb.200903033

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806328/
https://www.ncbi.nlm.nih.gov/pubmed/19995934
http://dx.doi.org/10.1083/jcb.200903033

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