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Flux regulation of cardiac ryanodine receptor channels

The cardiac type 2 ryanodine receptor (RYR2) is activated by Ca(2+)-induced Ca(2+) release (CICR). The inherent positive feedback of CICR is well controlled in cells, but the nature of this control is debated. Here, we explore how the Ca(2+) flux (lumen-to-cytosol) carried by an open RYR2 channel in...

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Detalles Bibliográficos
Autores principales: Liu, Yiwei, Porta, Maura, Qin, Jia, Ramos, Jorge, Nani, Alma, Shannon, Thomas R., Fill, Michael
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806413/
https://www.ncbi.nlm.nih.gov/pubmed/20008518
http://dx.doi.org/10.1085/jgp.200910273