Epac1 mediates protein kinase A–independent mechanism of forskolin-activated intestinal chloride secretion

Intestinal Cl(−) secretion is stimulated by cyclic AMP (cAMP) and intracellular calcium ([Ca(2+)](i)). Recent studies show that protein kinase A (PKA) and the exchange protein directly activated by cAMP (Epac) are downstream targets of cAMP. Therefore, we tested whether both PKA and Epac are involve...

Descripción completa

Detalles Bibliográficos
Autores principales: Hoque, Kazi Mirajul, Woodward, Owen M., van Rossum, Damian B., Zachos, Nicholas C., Chen, Linxi, Leung, George P.H., Guggino, William B., Guggino, Sandra E., Tse, Chung-Ming
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806414/
https://www.ncbi.nlm.nih.gov/pubmed/20038525
http://dx.doi.org/10.1085/jgp.200910339

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806414/
https://www.ncbi.nlm.nih.gov/pubmed/20038525
http://dx.doi.org/10.1085/jgp.200910339

Ejemplares similares