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Epac1 mediates protein kinase A–independent mechanism of forskolin-activated intestinal chloride secretion
Intestinal Cl(−) secretion is stimulated by cyclic AMP (cAMP) and intracellular calcium ([Ca(2+)](i)). Recent studies show that protein kinase A (PKA) and the exchange protein directly activated by cAMP (Epac) are downstream targets of cAMP. Therefore, we tested whether both PKA and Epac are involve...
| Autores principales: | , , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806414/ https://www.ncbi.nlm.nih.gov/pubmed/20038525 http://dx.doi.org/10.1085/jgp.200910339 |