An electrostatic interaction between TEA and an introduced pore aromatic drives spring-in-the-door inactivation in Shaker potassium channels

Slow inactivation of Kv1 channels involves conformational changes near the selectivity filter. We examine such changes in Shaker channels lacking fast inactivation by considering the consequences of mutating two residues, T449 just external to the selectivity filter and V438 in the pore helix near t...

Descripción completa

Detalles Bibliográficos
Autores principales: Ahern, Christopher A., Eastwood, Amy L., Dougherty, Dennis A., Horn, Richard
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806421/
https://www.ncbi.nlm.nih.gov/pubmed/19917730
http://dx.doi.org/10.1085/jgp.200910260

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806421/
https://www.ncbi.nlm.nih.gov/pubmed/19917730
http://dx.doi.org/10.1085/jgp.200910260

Ejemplares similares